Sofía Domínguez is a motherless girl who lives with her father, Dr. Antonio Domínguez, with her stepmother Mercedes and has a younger brother named Esteban. The latter two strive to make Sofía look bad whenever they can, while her father works all day in a laboratory. Sofia has several friends who are her neighbors and one day they decide to enter the "haunted mansion" on Villa Luz street, where a man named Chon lives and who worked for his late employer "Don Darvelio." When they enter, they will live great adventures and fight to defeat the evil forces of Helga, the "Great Witch" who constantly threatens Sofia's life due to a prophecy that she must fulfill.